Rémi Zallot

Rémi Zallot

Senior Lecturer (Associate Professor) in Biochemistry at Manchester Metropolitan University

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Dr. Rémi Zallot

Rémi Zallot is a Senior Lecturer (Associate Professor) in Biochemistry at Manchester Metropolitan University, UK, researching microbial genes and enzymes to advance drug discovery and human health.

Posts

EFI workshop at the launch of the Singapore National Centre for Engineering Biology

less than 1 minute read

Published:

In October I travelled to the National University of Singapore for the opening of the Singapore National Centre for Engineering Biology (NCEB) on 5 October, followed by the Singapore Enzyme Biology Week. I am grateful to Wen Shan Yew for inviting me. Wen Shan, John Gerlt (University of Illinois Urbana-Champaign) and I work together on the ongoing development of the Enzyme Function Initiative (EFI) web tools.

portfolio

Gene Graphics

Published:

A web application for visualizing genomic neighborhoods, published in Bioinformatics (2018).

publications

Polyphosphoinositides are enriched in plant membrane rafts and form microdomains in the plasma membrane

Published in Plant physiology, 2010

DOI: 10.1104/pp.109.149823

Recommended citation: Fabienne Furt, Sabine König, Jean-Jacques Bessoule, Françoise Sargueil, Rémi Zallot, Thomas Stanislas, Elodie Noirot, Jeanine Lherminier, Françoise Simon-Plas, Ingo Heilmann, Sébastien Mongrand. "Polyphosphoinositides are enriched in plant membrane rafts and form microdomains in the plasma membrane." Plant physiology, 2010.

Acyl-lipid metabolism

Published in The Arabidopsis book/American Society of Plant Biologists, 2010

DOI: 10.1199/tab.0133

Recommended citation: Yonghua Li-Beisson, Basil Shorrosh, Fred Beisson, Mats X. Andersson, Vincent Arondel, Philip D. Bates, Sébastien Baud, David Bird, Allan DeBono, Timothy P. Durrett, Rochus B. Franke, Ian A. Graham, Kenta Katayama, Amélie A. Kelly, Tony Larson, Jonathan E. Markham, Martine Miquel, Isabel Molina, Ikuo Nishida, Owen Rowland, Lacey Samuels, Katherine M. Schmid, Hajime Wada, Ruth Welti, Changcheng Xu, Rémi Zallot, John Ohlrogge. "Acyl-lipid metabolism." The Arabidopsis book/American Society of Plant Biologists, 2010.

Acyl-lipid metabolism

Published in The Arabidopsis book/American Society of Plant Biologists, 2013

DOI: 10.1199/tab.0161

Recommended citation: Yonghua Li-Beisson, Basil Shorrosh, Fred Beisson, Mats X. Andersson, Vincent Arondel, Philip D. Bates, Sébastien Baud, David Bird, Allan DeBono, Timothy P. Durrett, Rochus B. Franke, Ian A. Graham, Kenta Katayama, Amélie A. Kelly, Tony Larson, Jonathan E. Markham, Martine Miquel, Isabel Molina, Ikuo Nishida, Owen Rowland, Lacey Samuels, Katherine M. Schmid, Hajime Wada, Ruth Welti, Changcheng Xu, Rémi Zallot, John Ohlrogge. "Acyl-lipid metabolism." The Arabidopsis book/American Society of Plant Biologists, 2013.

Identification of mitochondrial coenzyme a transporters from maize and Arabidopsis

Published in Plant physiology, 2013

DOI: 10.1104/pp.113.218081

Recommended citation: Rémi Zallot, Gennaro Agrimi, Claudia Lerma-Ortiz, Howard J. Teresinski, Océane Frelin, Kenneth W. Ellens, Alessandra Castegna, Annamaria Russo, Valérie de Crécy-Lagard, Robert T. Mullen, Ferdinando Palmieri, Andrew D. Hanson. "Identification of mitochondrial coenzyme a transporters from maize and Arabidopsis." Plant physiology, 2013.

High-throughput comparison, functional annotation, and metabolic modeling of plant genomes using the PlantSEED resource

Published in Proceedings of the National Academy of Sciences, 2014

DOI: 10.1073/pnas.1401329111

Recommended citation: Samuel M. D. Seaver, Svetlana Gerdes, Océane Frelin, Claudia Lerma-Ortiz, Louis M. T. Bradbury, Rémi Zallot, Ghulam Hasnain, Thomas D. Niehaus, Basma El Yacoubi, Shiran Pasternak, Robert Olson, Gordon Pusch, Ross Overbeek, Rick Stevens, Valérie de Crécy-Lagard, Doreen Ware, Andrew D. Hanson, Christopher S. Henry. "High-throughput comparison, functional annotation, and metabolic modeling of plant genomes using the PlantSEED resource." Proceedings of the National Academy of Sciences, 2014.

Salvage of the thiamin pyrimidine moiety by plant TenA proteins lacking an active-site cysteine

Published in Biochemical Journal, 2014

DOI: 10.1042/bj20140522

Recommended citation: Rémi Zallot, Mohammad Yazdani, Aymeric Goyer, Michael J. Ziemak, Jiahn-Chou Guan, Donald R. McCarty, Valérie de Crécy-Lagard, Svetlana Gerdes, Timothy J. Garrett, Jordi Benach, John F. Hunt, David K. Shintani, Andrew D. Hanson. "Salvage of the thiamin pyrimidine moiety by plant TenA proteins lacking an active-site cysteine." Biochemical Journal, 2014.

Functional diversity of haloacid dehalogenase superfamily phosphatases from Saccharomyces cerevisiae: biochemical, structural, and evolutionary insights

Published in Journal of Biological Chemistry, 2015

DOI: 10.1074/jbc.m115.657916

Recommended citation: Ekaterina Kuznetsova, Boguslaw Nocek, Greg Brown, Kira S. Makarova, Robert Flick, Yuri I. Wolf, Anna Khusnutdinova, Elena Evdokimova, Ke Jin, Kemin Tan, Andrew D. Hanson, Ghulam Hasnain, Rémi Zallot, Valérie de Crécy-Lagard, Mohan Babu, Alexei Savchenko, Andrzej Joachimiak, Aled M. Edwards, Eugene V. Koonin, Alexander F. Yakunin. "Functional diversity of haloacid dehalogenase superfamily phosphatases from Saccharomyces cerevisiae: biochemical, structural, and evolutionary insights." Journal of Biological Chemistry, 2015.

A family of metal-dependent phosphatases implicated in metabolite damage-control

Published in Nature Chemical Biology, 2016

DOI: 10.1038/nchembio.2108

Recommended citation: Lili Huang, Anna Khusnutdinova, Boguslaw Nocek, Greg Brown, Xiaohui Xu, Hong Cui, Pierre Petit, Robert Flick, Rémi Zallot, Kelly Balmant, Michael J. Ziemak, John Shanklin, Valérie de Crécy-Lagard, Oliver Fiehn, Jesse F. Gregory, Andrzej Joachimiak, Alexei Savchenko, Alexander F. Yakunin, Andrew D. Hanson. "A family of metal-dependent phosphatases implicated in metabolite damage-control." Nature Chemical Biology, 2016.

Arabidopsis TH2 encodes the orphan enzyme thiamin monophosphate phosphatase

Published in The Plant Cell, 2016

DOI: 10.1105/tpc.16.00600

Recommended citation: Manaki Mimura, Rémi Zallot, Thomas D. Niehaus, Ghulam Hasnain, Satinder K. Gidda, Thuy N.D. Nguyen, Erin M. Anderson, Robert T. Mullen, Greg Brown, Alexander F. Yakunin, Valérie de Crécy-Lagard, Jesse F. Gregory, Donald R. McCarty, Andrew D. Hanson. "Arabidopsis TH2 encodes the orphan enzyme thiamin monophosphate phosphatase." The Plant Cell, 2016.

Systematic identification and analysis of frequent gene fusion events in metabolic pathways

Published in BMC genomics, 2016

DOI: 10.1186/s12864-016-2782-3

Recommended citation: Christopher S. Henry, Claudia Lerma-Ortiz, Svetlana Y. Gerdes, Jeffrey D. Mullen, Ric Colasanti, Aleksey Zhukov, Océane Frelin, Jennifer J. Thiaville, Rémi Zallot, Thomas D. Niehaus, Ghulam Hasnain, Neal Conrad, Andrew D. Hanson, Valérie de Crécy-Lagard. "Systematic identification and analysis of frequent gene fusion events in metabolic pathways." BMC genomics, 2016.

Functional assignment of multiple catabolic pathways for D-apiose

Published in Nature chemical biology, 2018

DOI: 10.1038/s41589-018-0067-7

Recommended citation: Michael S. Carter, Xinshuai Zhang, Hua Huang, Jason T. Bouvier, Brian San Francisco, Matthew W. Vetting, Nawar Al-Obaidi, Jeffrey B. Bonanno, Agnidipta Ghosh, Rémi Zallot, Harvey M. Andersen, Steven C. Almo, John A. Gerlt. "Functional assignment of multiple catabolic pathways for D-apiose." Nature chemical biology, 2018.

Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens

Published in Proceedings of the National Academy of Sciences, 2019

DOI: 10.1073/pnas.1909604116

Recommended citation: Yifeng Yuan, Rémi Zallot, Tyler L. Grove, Daniel J. Payan, Isabelle Martin-Verstraete, Sara Šepić, Seetharamsingh Balamkundu, Ramesh Neelakandan, Vinod K. Gadi, Chuan-Fa Liu, Manal A. Swairjo, Peter C. Dedon, Steven C. Almo, John A. Gerlt, Valérie de Crécy-Lagard. "Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens." Proceedings of the National Academy of Sciences, 2019.

Mechanistic and structural insights into the specificity and biological functions of bacterial sulfoglycosidases

Published in ACS Catalysis, 2023

DOI: 10.1021/acscatal.2c05405

Recommended citation: Zhen Zhang, Mochen Dong, Rémi Zallot, George Michael Blackburn, Nini Wang, Chengjian Wang, Long Chen, Patrick Baumann, Zuyan Wu, Zhongfu Wang, Haiming Fan, Christian Roth, Yi Jin, Yuan He. "Mechanistic and structural insights into the specificity and biological functions of bacterial sulfoglycosidases." ACS Catalysis, 2023.

Biosynthesis and function of 7-deazaguanine derivatives in bacteria and phages

Published in Microbiology and Molecular Biology Reviews, 2024

DOI: 10.1128/mmbr.00199-23

Recommended citation: Valérie de Crécy-Lagard, Geoffrey Hutinet, José D. D. Cediel-Becerra, Yifeng Yuan, Rémi Zallot, Marc G. Chevrette, R. M. Madhushi N. Ratnayake, Marshall Jaroch, Samia Quaiyum, Steven Bruner. "Biosynthesis and function of 7-deazaguanine derivatives in bacteria and phages." Microbiology and Molecular Biology Reviews, 2024.

Cryptic enzymatic assembly of peptides armed with β-lactone warheads

Published in Nature chemical biology, 2024

DOI: 10.1038/s41589-024-01657-7

Recommended citation: Guangcai Xu, Daniele Torri, Sebastian Cuesta-Hoyos, Deepanjan Panda, Luke R. L. Yates, Rémi Zallot, Kehan Bian, Dongxu Jia, Andreea I. Iorgu, Colin Levy, Sarah A. Shepherd, Jason Micklefield. "Cryptic enzymatic assembly of peptides armed with β-lactone warheads." Nature chemical biology, 2024.

A cloaked glutamate decarboxylase sustains the GABA shunt in Mycobacterium tuberculosis

Published in Proceedings of the National Academy of Sciences, 2026

DOI: 10.1073/pnas.2619778123

Recommended citation: Hai Minh Thai, Debbie M. Hunt, Yugen Miyahara, Manisha Priya, Htin L. Aung, Rémi Zallot, Luiz Pedro S. de Carvalho. "A cloaked glutamate decarboxylase sustains the GABA shunt in Mycobacterium tuberculosis." Proceedings of the National Academy of Sciences, 123(34), e2619778123, 2026.

Characterization of putatively lytic bacteriophages able to infect Xanthomonas citri subsp. citri and identification of novel putative exopolysaccharide depolymerases

Published in Microbial Genomics, 2026

DOI: 10.1099/mgen.0.001821

Recommended citation: Caio Felipe Cavicchia Zamunér, Roobinidevi Ragupathy, Mateus S. Terceti, Rémi Zallot, James Redfern, Jeffrey B. Jones, Franklin Behlau, Henrique Ferreira, Mark C. Enright. "Characterization of putatively lytic bacteriophages able to infect Xanthomonas citri subsp. citri and identification of novel putative exopolysaccharide depolymerases." Microbial Genomics, 12(9), 001821, 2026.

talks

teaching

Biomedical Cell Biology (BCB)

Module Leader, Manchester Metropolitan University, School of Biological and Chemical Sciences, 2023

I am the Module Leader for Biomedical Cell Biology (BCB), a final-year optional module for students on the accredited Biomedical Science programme.